KMID : 0388220140210050241
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Journal of the Korean Rheumatism Association 2014 Volume.21 No. 5 p.241 ~ p.247
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Sleep Disturbances in Korean Patients with Ankylosing Spondylitis are Associated with Increased Disease Activity
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Jung Hye-Jin
Lee Tae-Han Lee Ji-Min Choi Go Son Chang-Nam Kim Ji-Min Cho Yong-Won Kim Sang-Hyon Kim Sang-Hyon
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Abstract
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Objective. To evaluate the prevalence of sleep disturbance in Korean patients with ankylosing spondylitis (AS), and its association with disease activity and depression.
Methods. Forty patients with AS and eighty healthy con-trols were included in this study. Sleep quality was as-sessed using the Korean version of Pittsburgh sleep quality index (PSQI). Depression was assessed by the Korean ver-sion of Beck depression inventory second edition (BDI-2). Ankylosing spondylitis disease activity score-C-reactive protein (ASDAS-CRP) was used to evaluate disease activity. Patients were dichotomized into a good sleeper group (PSQI¡Â5) and a poor sleeper group (PSQI£¾5).
Results. The mean total PSQI score of patients with AS was 7.23¡¾3.84. It was higher than that of the control subjects. AS patients had higher scores in all of the PSQI compo-nents, except for the use of sleep medication. Sixty percent of the AS patients were classified as poor sleepers. The mean BASDAI, ASDAS-CRP, and BDI-2 scores of the poor sleeper group were higher than that of the good sleeper group. Significantly, higher disease activity according to ASDAS-CRP was associated with poor sleep quality and depression. Multiple regression analysis revealed that the duration of morning stiffness and depression were in-dependent risk factors that influenced poor sleep quality.
Conclusion. Sleep disturbances are prevalent amongst Korean patients with AS. Lower quality of sleep is sig-nificantly associated with higher disease activity and depression. Therefore, optimal management to improve sleep quality in patients with AS is important.
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KEYWORD
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Ankylosing spondylitis, Disease activity, Sleep quality, Depression
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